Slovenian National Institute of Biology and University Medical Centre Ljubljana, with MGC Pharma Research and Development Division, conducted the study about the treatment of high-grade brain tumours, i.e. glioblastoma with cannabinoids. The general aim of the research was to develop formulations to define the protocols for the treatment.
Study evaluated cannabinoid receptor proteins that may add to identify the most effective cytotoxic cannabinoids, known so far, e.g. CBD and THC ratios and further their possible synergistic effects with chemotherapeutic Temozolomide (‘TMZ’) with regards to the treatment of glioblastoma patients.
Conclusions of the study
Cannabinoids, especially at increasing THC concentrations, reduce the viability of glioblastoma cells.
Targeting glioblastoma stem cells (GSCs) that are more resistant to chemotherapy. GSC has so far proved to be more vulnerable to cannabinoids than were differentiated cell (publication in preparation).
At optimal concentration for each patient, the defined cannabinoids composition represents promising tool to reduce tumour burden.
Research collaboration is part of MGC Pharma’s strategy of partnering with leading research institutions to examine opportunities to develop new pharma products based on proven cannabinoid formulations in pre-and clinical studies.
The study results can be viewed on the Company’s website and will be presented by the National Institute of Biology at the 2nd International Annual Congress on Controversies on Cannabis-Based Medicines in Barcelona, Spain on 23-24 May 2019.
The CannaPaed Symposium 2019 will be held in Ljubljana on 25th of January 2019. The Symposium is intended for anyone taking care of children with pharmacoresistant epilepsy as well as children with other medical conditions such as dystonia, autism or cancer that could benefit from treatment with medicines derived from cannabis.
The invited speakers will present you the basics of endocannabinoid system, the mode of action and the importance of different strains for different disease conditions in pediatrics. The symposium is designed for those taking care of children, from those in training to those with years of experience.
More about the event is available following this link>>>>
What is the evidence base for the medical use of cannabis and cannabinoids? What is the difference between cannabis preparations and medicinal products and why is this important? How is this issue regulated in the EU? These and other questions are explored in a new report published today by the EU drugs agency (EMCDDA): Medical use of cannabis and cannabinoids: questions and answers for policymaking. The report responds to growing interest in this topic as more European countries develop policies and practice in this area.
ʻMany EU countries now allow, or are considering allowing, the medical use of cannabis or cannabinoids in some formʼ, states the report. But approaches vary widely between countries, both in terms of the products permitted and the regulatory frameworks governing their provision. Understanding this variety of national approaches is important for an informed policy debate in this area in the EU.
The report aims to explore current practice in the EU regarding the provision of these substances for medical purposes and clarify some of the complex issues in this area in order to support science, policy and practice. The report notes that the terms ʻmedical use of cannabis and cannabinoidsʼ can refer to a wide variety of products and preparations that may contain different active ingredients and use different routes of administration.
The publication provides a state-of-the-art overview of evidence for the medical use of cannabis and cannabinoids. It concludes that more research and clinical studies are needed to fill ʻimportant gaps in the evidenceʼ.
The report highlights the challenges of decision-making in this area and summarises the multiple issues that governments may consider when deciding whether to make cannabis or cannabinoids available for medical use. These include: the types of product that patients will be allowed to use; the medical conditions for which such products can be used; and the type of medical and regulatory supervision under which patients are allowed to use them.
EMCDDA Director Alexis Goosdeel says: ‘In most countries, the provision of cannabis and cannabinoid products and preparations for medical purposes has evolved over time, often in response to patient demand or product development. This report seeks to provide an objective look at current evidence, practice and experience in this very fast-moving field and describe the complex patchwork of approaches adopted in the EU and beyond. Lastly, it points to the importance of developing a common language on this issue to help build a base for evaluation and assessmentʼ.
To read the report, follow this link>>>>