Slovenian National Institute of Biology and University Medical Centre Ljubljana, with MGC Pharma Research and Development Division, conducted the study about the treatment of high-grade brain tumours, i.e. glioblastoma with cannabinoids. The general aim of the research was to develop formulations to define the protocols for the treatment.
Study evaluated cannabinoid receptor proteins that may add to identify the most effective cytotoxic cannabinoids, known so far, e.g. CBD and THC ratios and further their possible synergistic effects with chemotherapeutic Temozolomide (‘TMZ’) with regards to the treatment of glioblastoma patients.
Conclusions of the study
Cannabinoids, especially at increasing THC concentrations, reduce the viability of glioblastoma cells.
Targeting glioblastoma stem cells (GSCs) that are more resistant to chemotherapy. GSC has so far proved to be more vulnerable to cannabinoids than were differentiated cell (publication in preparation).
At optimal concentration for each patient, the defined cannabinoids composition represents promising tool to reduce tumour burden.
Research collaboration is part of MGC Pharma’s strategy of partnering with leading research institutions to examine opportunities to develop new pharma products based on proven cannabinoid formulations in pre-and clinical studies.
The study results can be viewed on the Company’s website and will be presented by the National Institute of Biology at the 2nd International Annual Congress on Controversies on Cannabis-Based Medicines in Barcelona, Spain on 23-24 May 2019.